These patients with intense eosinophilic responses (> 650 cells/μL) were referred to the parasitology department and had florid intestinal infections. This is the first report of this pathologic combination in Latin American children.Ī cohort of six eutrophic otherwise healthy children less than 12 years of age were referred to our hemostasis unit due to mild dermal and mucosal bleeding episodes, mainly represented by variable-size ecchymoses (1.5–8 cm) mostly confined to the upper and lower extremities. The possible pathogenic roles of eosinophilia and parasitism are reviewed. Thrombocytopathic features mimicked the intrinsic defect of storage pool disease. No relationship could be established between excess eosinophils, intensity of bleeding, or type and degree of platelet abnormalities. Anti-parasite therapy reversed the hemorrhagic manifestations and normalized eosinophil counts and platelet alterations. Antibodies to platelets were not detected. Main abnormalities included prolonged bleeding times (50%) and defective aggregation with collagen (100%) adrenaline (66%), or ADP (66%). All children showed intestinal parasites and marked eosinophilia (mean count = 2,615.2 cells/μL, 95% confidence interval = 1,259.6–5,429.8). Mild bleeding phenomena (ecchymoses, petechiae, epistaxis, and gingival) were transient. We conducted clinical evaluations, hematologic and platelet function tests, clotting studies (bleeding time, prothrombin time, partial thromboplastin time, thrombin time, factor XIII, factor VIII, and von Willebrand factor), assays for IgG and IgM antibodies to platelets, and a search for stool parasites. Platelet dysfunction was detected in six children with purpura and eosinophilia. "Bernard-Soulier Syndrome Workup: Approach Considerations". ^ "CBC (Complete Blood Count), Blood"."The impact of various platelet indices as prognostic markers of septic shock". ^ Gao Y, Li Y, Yu X, Guo S, Ji X, Sun T, et al.Indian Journal of Hematology & Blood Transfusion: 1–9. "Platelet Indices and Their Kinetics Predict Mortality in Patients of Sepsis". ^ Mangalesh S, Dudani S, Malik A (March 2021)."Mean platelet volume: a controversial marker of disease activity in Crohn's disease". ^ Liu S, Ren J, Han G, Wang G, Gu G, Xia Q, Li J (October 2012).Archives of Pathology & Laboratory Medicine. "Increased mean platelet volume in patients with acute coronary syndromes". ^ Lippi G, Filippozzi L, Salvagno GL, Montagnana M, Franchini M, Guidi GC, Targher G (September 2009).Arteriosclerosis, Thrombosis, and Vascular Biology. ^ "Mean Platelet Volume May Represent a Predictive Parameter for Overall Vascular Mortality and Ischemic Heart Disease".Familial platelet disorder with predisposition to AML.Congenital amegakaryocytic thrombocytopenia.Inherited thrombocytopenia with normal MPV Administration of erythropoietin / thrombopoietin.Acquired Immunodeficiency Syndrome ( AIDS).A typical range of platelet volumes is 9.4–12.3 fL ( femtolitre), equivalent to spheres 2.65 to 2.9 µm in diameter.Ĭonditions associated with altered MPV Decreased MPV Sample for MPV testing is obtained in a Lavender-Top EDTA tube. In addition, low MPV may correlate with abnormally small platelet size, sometimes a symptom of a spectrum referred to as Wiskott–Aldrich syndrome (WAS), caused by a genetic mutation of the WAS gene. A high MPV is also a bad prognostic marker in patients with sepsis or septic shock. A low MPV may indicate inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis. Ībnormally low MPV values may correlate with thrombocytopenia when it is due to impaired production of megakaryocytes in the bone marrow, such as in aplastic anemia. It may also be related to pre-eclampsia and recovery from transient hypoplasia. This may be seen in immune thrombocytopenic purpura (ITP), myeloproliferative diseases and Bernard–Soulier syndrome. MPV may be higher when there is destruction of platelets. Īn increased mean platelet volume (MPV) increases the risk to suffer a heart disease Since the average platelet size is larger when the body is producing increased numbers of platelets, the MPV test results can be used to make inferences about platelet production in bone marrow or platelet destruction problems. Mean platelet volume ( MPV) is a machine-calculated measurement of the average size of platelets found in blood and is typically included in blood tests as part of the CBC. Can be used to make inferences about platelet production in bone marrow or platelet destruction problems
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